Rutgers University Chemistry (Biochemistry
Epigenetic states represent one of the most transformative discoveries in molecular biology over the past two decades, revealing fundamental mechanisms that govern gene expression, developmental processes, and the origins of many human diseases. This course introduces the principles of chromatin dynamics and the structural and biochemical modifications that underlie epigenetic regulation. Students will explore how epigenetic information is established, maintained, and inherited, gaining an understanding of the biochemical properties of chromatin and their impact on gene regulation. In addition, students will learn to use bioinformatic tools to analyze molecular structures and genomic sequencing data. The course emphasizes a holistic understanding of the eukaryotic nucleus, including the organization and evolution of genomes in unicellular and multicellular organisms, and the mechanisms that modulate chromatin. Students will present and discuss primary research articles to strengthen critical analysis skills, and several guest lectures will highlight cutting-edge technologies and emerging frontiers in epigenomics. (Instructors: Sam Guoping Gu and Mikel Zaratiegui.)
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